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human mtor signalling phospho-specific antibody microarray  (Full Moon BioSystems)

 
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    Full Moon BioSystems human mtor signalling phospho-specific antibody microarray
    Dysregulation of the <t>mTOR</t> signaling pathway. (A) . Heat map representation of phosphoprotein ratio detected in full moon Biosystems mTOR phospho-protein array. Fold change was calculated after normalizing the average signal cor-responding to the median signal for each group, and the ratio has been calculated as KO vs. WT signals. Proteins that have shown at least 2-fold up or downregulation were included. (B) . KO cells show less co-localization of mTOR (green) with the lysosome (LAMP1, red) in refed and starved conditions than WT cortical cells. Scale bar represents 10 um. (C,D) The total intensity of mTOR and LAMP1 was measured with cell profiler using immunostaining images in WT (C) and (D) KO. Graphs represent mean ± SEM; * p < 0.05, ** p < 0.01, Student’s t-test ( n = 15–17 images for each condition). (E–G) Data representation of the total mean of intensity of (E) mTOR and (F) LAMP1 in an area of interest in the cytoplasm (doughnut) of WT cells at different conditions, respectively. Whispers max and min plot represent total mTOR and total LAMP1 intensity in the cell. (G) mTOR and LAMP1 correlation in basal, starved, and refed conditions. The graph rep-resents Pearson’s co-efficient correlation between LAMP1 and total mTOR in WT and KO cells. (H–L) Bar graph represents changed upstream protein phosphorylation changes at basal (H) , starved (J) , and refed (L) conditions. Further repre-sentation of phosphorylated target of downstream regulators altered at basal (I) , starved (K) , and refed conditions (M) . (N,O) Further targeted protein changed from the transition from basal to starved upstream regulators (N) and downstream regulators (O) . (I,K) represents affected proteins between trans ion from starved to refed, upstream regulators (P) and downstream regulators (Q) .
    Human Mtor Signalling Phospho Specific Antibody Microarray, supplied by Full Moon BioSystems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human mtor signalling phospho-specific antibody microarray/product/Full Moon BioSystems
    Average 90 stars, based on 1 article reviews
    human mtor signalling phospho-specific antibody microarray - by Bioz Stars, 2026-03
    90/100 stars

    Images

    1) Product Images from "SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells"

    Article Title: SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells

    Journal: Frontiers in Cell and Developmental Biology

    doi: 10.3389/fcell.2022.854397

    Dysregulation of the mTOR signaling pathway. (A) . Heat map representation of phosphoprotein ratio detected in full moon Biosystems mTOR phospho-protein array. Fold change was calculated after normalizing the average signal cor-responding to the median signal for each group, and the ratio has been calculated as KO vs. WT signals. Proteins that have shown at least 2-fold up or downregulation were included. (B) . KO cells show less co-localization of mTOR (green) with the lysosome (LAMP1, red) in refed and starved conditions than WT cortical cells. Scale bar represents 10 um. (C,D) The total intensity of mTOR and LAMP1 was measured with cell profiler using immunostaining images in WT (C) and (D) KO. Graphs represent mean ± SEM; * p < 0.05, ** p < 0.01, Student’s t-test ( n = 15–17 images for each condition). (E–G) Data representation of the total mean of intensity of (E) mTOR and (F) LAMP1 in an area of interest in the cytoplasm (doughnut) of WT cells at different conditions, respectively. Whispers max and min plot represent total mTOR and total LAMP1 intensity in the cell. (G) mTOR and LAMP1 correlation in basal, starved, and refed conditions. The graph rep-resents Pearson’s co-efficient correlation between LAMP1 and total mTOR in WT and KO cells. (H–L) Bar graph represents changed upstream protein phosphorylation changes at basal (H) , starved (J) , and refed (L) conditions. Further repre-sentation of phosphorylated target of downstream regulators altered at basal (I) , starved (K) , and refed conditions (M) . (N,O) Further targeted protein changed from the transition from basal to starved upstream regulators (N) and downstream regulators (O) . (I,K) represents affected proteins between trans ion from starved to refed, upstream regulators (P) and downstream regulators (Q) .
    Figure Legend Snippet: Dysregulation of the mTOR signaling pathway. (A) . Heat map representation of phosphoprotein ratio detected in full moon Biosystems mTOR phospho-protein array. Fold change was calculated after normalizing the average signal cor-responding to the median signal for each group, and the ratio has been calculated as KO vs. WT signals. Proteins that have shown at least 2-fold up or downregulation were included. (B) . KO cells show less co-localization of mTOR (green) with the lysosome (LAMP1, red) in refed and starved conditions than WT cortical cells. Scale bar represents 10 um. (C,D) The total intensity of mTOR and LAMP1 was measured with cell profiler using immunostaining images in WT (C) and (D) KO. Graphs represent mean ± SEM; * p < 0.05, ** p < 0.01, Student’s t-test ( n = 15–17 images for each condition). (E–G) Data representation of the total mean of intensity of (E) mTOR and (F) LAMP1 in an area of interest in the cytoplasm (doughnut) of WT cells at different conditions, respectively. Whispers max and min plot represent total mTOR and total LAMP1 intensity in the cell. (G) mTOR and LAMP1 correlation in basal, starved, and refed conditions. The graph rep-resents Pearson’s co-efficient correlation between LAMP1 and total mTOR in WT and KO cells. (H–L) Bar graph represents changed upstream protein phosphorylation changes at basal (H) , starved (J) , and refed (L) conditions. Further repre-sentation of phosphorylated target of downstream regulators altered at basal (I) , starved (K) , and refed conditions (M) . (N,O) Further targeted protein changed from the transition from basal to starved upstream regulators (N) and downstream regulators (O) . (I,K) represents affected proteins between trans ion from starved to refed, upstream regulators (P) and downstream regulators (Q) .

    Techniques Used: Protein Array, Immunostaining, Phospho-proteomics

    The response in mTOR pathway and amino acid regualtion following SLC38A10 knockout. Complete transcriptomic data and changed gene list subjected to IPA software analysis. (A) Regulation in the mTOR pathway in response to SLC38A10 knockout in Basal condition, blue symbols indicate down regulation and red symbols up regulation. (B) Heatmap describing changes in transcript levels from the mTOR pathway during Basal, Starved and Refed conditions. (C) Heatmap describing changes in transcript levels from the p70S6 pathway during Basal, Starved and Refed conditions. (D) Regulation in the mTOR pathway in response to SLC38A10 knockout in Starved condition, blue symbols indicate down regulation and red symbols up regulation. (E) Regulation in the mTOR pathway in response to SLC38A10 knockout in Refed condition, blue symbols indicate down regulation and red symbols up regulation. (F) Neurological diseases predicted by Path Designer, in response to SLC38A10 knockout.
    Figure Legend Snippet: The response in mTOR pathway and amino acid regualtion following SLC38A10 knockout. Complete transcriptomic data and changed gene list subjected to IPA software analysis. (A) Regulation in the mTOR pathway in response to SLC38A10 knockout in Basal condition, blue symbols indicate down regulation and red symbols up regulation. (B) Heatmap describing changes in transcript levels from the mTOR pathway during Basal, Starved and Refed conditions. (C) Heatmap describing changes in transcript levels from the p70S6 pathway during Basal, Starved and Refed conditions. (D) Regulation in the mTOR pathway in response to SLC38A10 knockout in Starved condition, blue symbols indicate down regulation and red symbols up regulation. (E) Regulation in the mTOR pathway in response to SLC38A10 knockout in Refed condition, blue symbols indicate down regulation and red symbols up regulation. (F) Neurological diseases predicted by Path Designer, in response to SLC38A10 knockout.

    Techniques Used: Knock-Out, Software



    Similar Products

    human mtor signalling phospho-specific antibody microarray  (Full Moon BioSystems)
    90
    Full Moon BioSystems human mtor signalling phospho-specific antibody microarray
    Dysregulation of the <t>mTOR</t> signaling pathway. (A) . Heat map representation of phosphoprotein ratio detected in full moon Biosystems mTOR phospho-protein array. Fold change was calculated after normalizing the average signal cor-responding to the median signal for each group, and the ratio has been calculated as KO vs. WT signals. Proteins that have shown at least 2-fold up or downregulation were included. (B) . KO cells show less co-localization of mTOR (green) with the lysosome (LAMP1, red) in refed and starved conditions than WT cortical cells. Scale bar represents 10 um. (C,D) The total intensity of mTOR and LAMP1 was measured with cell profiler using immunostaining images in WT (C) and (D) KO. Graphs represent mean ± SEM; * p < 0.05, ** p < 0.01, Student’s t-test ( n = 15–17 images for each condition). (E–G) Data representation of the total mean of intensity of (E) mTOR and (F) LAMP1 in an area of interest in the cytoplasm (doughnut) of WT cells at different conditions, respectively. Whispers max and min plot represent total mTOR and total LAMP1 intensity in the cell. (G) mTOR and LAMP1 correlation in basal, starved, and refed conditions. The graph rep-resents Pearson’s co-efficient correlation between LAMP1 and total mTOR in WT and KO cells. (H–L) Bar graph represents changed upstream protein phosphorylation changes at basal (H) , starved (J) , and refed (L) conditions. Further repre-sentation of phosphorylated target of downstream regulators altered at basal (I) , starved (K) , and refed conditions (M) . (N,O) Further targeted protein changed from the transition from basal to starved upstream regulators (N) and downstream regulators (O) . (I,K) represents affected proteins between trans ion from starved to refed, upstream regulators (P) and downstream regulators (Q) .
    Human Mtor Signalling Phospho Specific Antibody Microarray, supplied by Full Moon BioSystems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human mtor signalling phospho-specific antibody microarray/product/Full Moon BioSystems
    Average 90 stars, based on 1 article reviews
    human mtor signalling phospho-specific antibody microarray - by Bioz Stars, 2026-03
    90/100 stars
    		  Buy from Supplier
    human mtor signaling phospho-specific antibody microarray  (Full Moon BioSystems)
    90
    Full Moon BioSystems human mtor signaling phospho-specific antibody microarray
    Dysregulation of the <t>mTOR</t> signaling pathway. (A) . Heat map representation of phosphoprotein ratio detected in full moon Biosystems mTOR phospho-protein array. Fold change was calculated after normalizing the average signal cor-responding to the median signal for each group, and the ratio has been calculated as KO vs. WT signals. Proteins that have shown at least 2-fold up or downregulation were included. (B) . KO cells show less co-localization of mTOR (green) with the lysosome (LAMP1, red) in refed and starved conditions than WT cortical cells. Scale bar represents 10 um. (C,D) The total intensity of mTOR and LAMP1 was measured with cell profiler using immunostaining images in WT (C) and (D) KO. Graphs represent mean ± SEM; * p < 0.05, ** p < 0.01, Student’s t-test ( n = 15–17 images for each condition). (E–G) Data representation of the total mean of intensity of (E) mTOR and (F) LAMP1 in an area of interest in the cytoplasm (doughnut) of WT cells at different conditions, respectively. Whispers max and min plot represent total mTOR and total LAMP1 intensity in the cell. (G) mTOR and LAMP1 correlation in basal, starved, and refed conditions. The graph rep-resents Pearson’s co-efficient correlation between LAMP1 and total mTOR in WT and KO cells. (H–L) Bar graph represents changed upstream protein phosphorylation changes at basal (H) , starved (J) , and refed (L) conditions. Further repre-sentation of phosphorylated target of downstream regulators altered at basal (I) , starved (K) , and refed conditions (M) . (N,O) Further targeted protein changed from the transition from basal to starved upstream regulators (N) and downstream regulators (O) . (I,K) represents affected proteins between trans ion from starved to refed, upstream regulators (P) and downstream regulators (Q) .
    Human Mtor Signaling Phospho Specific Antibody Microarray, supplied by Full Moon BioSystems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human mtor signaling phospho-specific antibody microarray/product/Full Moon BioSystems
    Average 90 stars, based on 1 article reviews
    human mtor signaling phospho-specific antibody microarray - by Bioz Stars, 2026-03
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Dysregulation of the mTOR signaling pathway. (A) . Heat map representation of phosphoprotein ratio detected in full moon Biosystems mTOR phospho-protein array. Fold change was calculated after normalizing the average signal cor-responding to the median signal for each group, and the ratio has been calculated as KO vs. WT signals. Proteins that have shown at least 2-fold up or downregulation were included. (B) . KO cells show less co-localization of mTOR (green) with the lysosome (LAMP1, red) in refed and starved conditions than WT cortical cells. Scale bar represents 10 um. (C,D) The total intensity of mTOR and LAMP1 was measured with cell profiler using immunostaining images in WT (C) and (D) KO. Graphs represent mean ± SEM; * p < 0.05, ** p < 0.01, Student’s t-test ( n = 15–17 images for each condition). (E–G) Data representation of the total mean of intensity of (E) mTOR and (F) LAMP1 in an area of interest in the cytoplasm (doughnut) of WT cells at different conditions, respectively. Whispers max and min plot represent total mTOR and total LAMP1 intensity in the cell. (G) mTOR and LAMP1 correlation in basal, starved, and refed conditions. The graph rep-resents Pearson’s co-efficient correlation between LAMP1 and total mTOR in WT and KO cells. (H–L) Bar graph represents changed upstream protein phosphorylation changes at basal (H) , starved (J) , and refed (L) conditions. Further repre-sentation of phosphorylated target of downstream regulators altered at basal (I) , starved (K) , and refed conditions (M) . (N,O) Further targeted protein changed from the transition from basal to starved upstream regulators (N) and downstream regulators (O) . (I,K) represents affected proteins between trans ion from starved to refed, upstream regulators (P) and downstream regulators (Q) .

    Journal: Frontiers in Cell and Developmental Biology

    Article Title: SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells

    doi: 10.3389/fcell.2022.854397

    Figure Lengend Snippet: Dysregulation of the mTOR signaling pathway. (A) . Heat map representation of phosphoprotein ratio detected in full moon Biosystems mTOR phospho-protein array. Fold change was calculated after normalizing the average signal cor-responding to the median signal for each group, and the ratio has been calculated as KO vs. WT signals. Proteins that have shown at least 2-fold up or downregulation were included. (B) . KO cells show less co-localization of mTOR (green) with the lysosome (LAMP1, red) in refed and starved conditions than WT cortical cells. Scale bar represents 10 um. (C,D) The total intensity of mTOR and LAMP1 was measured with cell profiler using immunostaining images in WT (C) and (D) KO. Graphs represent mean ± SEM; * p < 0.05, ** p < 0.01, Student’s t-test ( n = 15–17 images for each condition). (E–G) Data representation of the total mean of intensity of (E) mTOR and (F) LAMP1 in an area of interest in the cytoplasm (doughnut) of WT cells at different conditions, respectively. Whispers max and min plot represent total mTOR and total LAMP1 intensity in the cell. (G) mTOR and LAMP1 correlation in basal, starved, and refed conditions. The graph rep-resents Pearson’s co-efficient correlation between LAMP1 and total mTOR in WT and KO cells. (H–L) Bar graph represents changed upstream protein phosphorylation changes at basal (H) , starved (J) , and refed (L) conditions. Further repre-sentation of phosphorylated target of downstream regulators altered at basal (I) , starved (K) , and refed conditions (M) . (N,O) Further targeted protein changed from the transition from basal to starved upstream regulators (N) and downstream regulators (O) . (I,K) represents affected proteins between trans ion from starved to refed, upstream regulators (P) and downstream regulators (Q) .

    Article Snippet: Human mTOR signalling Phospho-Specific Antibody Microarray was purchased from Full moon Biosystems.

    Techniques: Protein Array, Immunostaining, Phospho-proteomics

    The response in mTOR pathway and amino acid regualtion following SLC38A10 knockout. Complete transcriptomic data and changed gene list subjected to IPA software analysis. (A) Regulation in the mTOR pathway in response to SLC38A10 knockout in Basal condition, blue symbols indicate down regulation and red symbols up regulation. (B) Heatmap describing changes in transcript levels from the mTOR pathway during Basal, Starved and Refed conditions. (C) Heatmap describing changes in transcript levels from the p70S6 pathway during Basal, Starved and Refed conditions. (D) Regulation in the mTOR pathway in response to SLC38A10 knockout in Starved condition, blue symbols indicate down regulation and red symbols up regulation. (E) Regulation in the mTOR pathway in response to SLC38A10 knockout in Refed condition, blue symbols indicate down regulation and red symbols up regulation. (F) Neurological diseases predicted by Path Designer, in response to SLC38A10 knockout.

    Journal: Frontiers in Cell and Developmental Biology

    Article Title: SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells

    doi: 10.3389/fcell.2022.854397

    Figure Lengend Snippet: The response in mTOR pathway and amino acid regualtion following SLC38A10 knockout. Complete transcriptomic data and changed gene list subjected to IPA software analysis. (A) Regulation in the mTOR pathway in response to SLC38A10 knockout in Basal condition, blue symbols indicate down regulation and red symbols up regulation. (B) Heatmap describing changes in transcript levels from the mTOR pathway during Basal, Starved and Refed conditions. (C) Heatmap describing changes in transcript levels from the p70S6 pathway during Basal, Starved and Refed conditions. (D) Regulation in the mTOR pathway in response to SLC38A10 knockout in Starved condition, blue symbols indicate down regulation and red symbols up regulation. (E) Regulation in the mTOR pathway in response to SLC38A10 knockout in Refed condition, blue symbols indicate down regulation and red symbols up regulation. (F) Neurological diseases predicted by Path Designer, in response to SLC38A10 knockout.

    Article Snippet: Human mTOR signalling Phospho-Specific Antibody Microarray was purchased from Full moon Biosystems.

    Techniques: Knock-Out, Software